Intended for use by local health departments (LHDs) as part of a multi-sector effort to coordinate planning for and response to a pandemic influenza outbreak, the 60-page guide offers the following: An overview of key issues that should be considered for inclusion in a local jurisdiction's pandemic influenza plan. An examination within each issue area of questions that should be asked, ideas on where to find information that may be needed, and partners that could be consulted to address those topics within the plan. Examples of ways in which other jurisdictions have addressed the topics described in the guide. Links to information that can be used to further investigate the topics or resources that can be used to customize tools for individual jurisdictions. At the core of this guide are plans developed by departments that host two of NACCHO's Advanced Practice Centera, cutting-edge learning laboratories that develop and test tools that help other LHDs tackle all-hazards preparedness. Santa Clara County, California and Seattle-King County, Washington, have both produced notably comprehensive, but very different, plans addressing pandemic influenza that serve as the foundation of this document's findings.